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Cialis is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED). It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped.
Mechanism of action
Although Viagra, Levitra and Cialis all work by inhibiting PDE5, Cialis work much longer (17.50 hours) – compared to Viagra (4.0–5.0 hours) and Levitra (4.0–5.0 hours). That’s why Cialis is known as “The Weekend Pill”.
The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Cialis inhibits PDE5 and sexual stimulation is required to initiate the erection. The recommended Cialis starting dose for most men is 10 mg, taken as needed before sexual activity (but not more than once daily). The dose may be increased to 20 mg or decreased to 5 mg, per its efficacy and the man’s personal tolerance of the drug.
Side effects
The most common side effects when using Cialis are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.
Drug interactions
Since Cialis may cause transiently low blood pressure, organic nitrates should not be taken for at least 48 hours after taking the last dose of Cialis. Using organic nitrites (such as the sex drug amyl nitrite) within this timeframe may increase the risk of life-threatening hypotension.
Since people who have taken Cialis within the past 48 hours cannot take organic nitrates to relieve angina (such as glyceryl trinitrate spray), these patients should seek immediate medical attention if they experience anginal chest pain.